Project Code
MRCPHS26Br Stevenson
Project Type
Wet lab
Research Theme
Population Health Science
Project Summary Download
Summary
Nearly 8% of the global population is living with osteoarthritis. The mechanisms of disease are poorly understood, however a major risk factor is altered mechanical loading of joints. This PhD project will investigate how the Golgi apparatus, a secretory pathway organelle, responds to mechanical signals and whether dysregulated extracellular matrix secretion contributes to osteoarthritis cartilage pathology. Analysis of GWAS studies will be used to identify osteoarthritis-linked Golgi proteins involved in disease progression, that will then be studied experimentally in 3D human cell culture and mouse tissue models of osteoarthritis. This is an exciting opportunity to uncover a novel cellular mechanism in joint disease.
Lead Supervisor
Dr Nicola Stevenson
Lead Supervisor Email
nicola.stevenson@bristol.ac.uk
University Affiliation
Bristol