Project Code
MRCNMH26Ex Ryu
Project Type
Wet lab
Research Theme
Neuroscience and Mental Health
Project Summary Download
Summary
Schizophrenia is a severe psychiatric disorder with debilitating effects on a patient’s quality of life. Because current medications do not work well, we need to study its molecular cause to develop new therapeutics. Recent research identified a number of genetic mutations in Schizophrenia patients called “rare coding variants.” These mutations change the proteins they produce, but for many of them, we do not yet know the functional consequences. In this project we will study the functions of the rare coding variants using zebrafish and compare the results with mouse models of equivalent mutations and human post-mortem brain tissue.
Lead Supervisor
Professor Soojin Ryu
Lead Supervisor Email
University Affiliation
Exeter