Hidden codes: Genetic Determinants of HIV-1 Fitness and Immune Recognition

Project Code

MRCIIAR26Br Mann

Project Type

Wet lab

Research Theme

Infection, Immunity, Antimicrobial Resistance and Repair

Project Summary Download

Summary

This project addresses the ongoing challenge posed by HIV-1, a virus infecting approximately 38 million people globally, with Subtype C (C-HIV) as the most prevalent strain. Understanding why C-HIV has become predominant in certain regions of the world is crucial for deciphering its transmission dynamics and impact. Through advanced genetic analysis coupled with state-of-the-art immunological and virological experimental techniques, we aim to uncover the genetic determinants driving C-HIV’s success. This research will deepen our understanding of HIV-1 evolution and help develop innovative strategies to combat the virus and mitigate its impact.

Lead Supervisor

Dr Jamie Mann

Lead Supervisor Email

jamie.mann@bristol.ac.uk

University Affiliation

Bristol