Project Code
MRCPHS26Ex Frontini
Project Type
Dry lab
Research Theme
Population Health Science
Project Summary Download
Summary
Proteins are the ultimate effector of the information encoded in the genome. Their effects are modulated by human genetic variation both qualitatively (changes in protein sequence) and quantitatively (changes in protein abundance). The candidate will use a large cohort of paired gene expression (RNA-seq) and proteomic (mass-spec) data from primary cells isolated from volunteers to determine how common genetic variation affects protein abundance and, through this mechanism, risk for human diseases.
Lead Supervisor
Dr Mattia Frontini
Lead Supervisor Email
University Affiliation
Exeter