Project Code
MRCNMH26Ex Lunnon
Project Type
Wet lab
Research Theme
Neuroscience and Mental Health
Project Summary Download
Summary
Huntington’s disease (HD) is a neurodegenerative disorder caused by a CAG expansion in the HTT gene, with age of onset influenced by additional genetic and environmental factors. This PhD project will investigate the role of microRNAs—key post-transcriptional regulators—in mediating this variability. Using cutting-edge short- and long-read sequencing technologies in post-mortem HD brain tissue, the project will identify microRNA signatures associated with age of onset and pathology, and relate these to transcriptional changes and genetics. Functional validation will be performed in an iPSC model of HTT expansion. The student will receive interdisciplinary training in genomics, neuroscience, stem cell models and bioinformatics.
Lead Supervisor
Professor Katie Lunnon
Lead Supervisor Email
University Affiliation
Exeter