Project Code
MRCNMH26Br Mellor
Project Type
Wet lab
Research Theme
Neuroscience and Mental Health
Project Summary Download
Summary
Genetic risk factors for schizophrenia are clustered around genes that regulate synaptic function and adaptation, pointing to underlying biological processes whose disruption leads to cognitive impairments in memory and flexible learning seen in schizophrenia. We have revealed how loss of function in some of these genes perturbs core features of synaptic signalling and adaptation. In this project, we aim to link these mechanisms to abnormal cognition using high resolution imaging in mice to directly measure neuronal adaptations during tasks demanding cognitive flexibility. We will then test mechanisms and drugs to rescue cognition as a step towards new treatments for schizophrenia.
Lead Supervisor
Professor Jack Mellor
Lead Supervisor Email
University Affiliation
Bristol