Project Code MRCIIAR25Ca Stanton Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary Neutralizing antibodies are key to preventing transmission of SARS-CoV-2, however the virus can rapidly mutate to avoid these. Furthermore, once infected, neutralizing antibodies cannot…
New antibiotics to kill “Superbugs” by stopping them from dividing
Project Code MRCIIAR25Ca Serpi Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary While antibiotics have revolutionised the landscape of medicine saving millions of lives, their misuse has also resulted in the rise of “Superbugs”, which are…
Design, synthesis and biological evaluation of molecules to tackle invasive fungal infections
Project Code MRCIIAR25Ca Pertusati Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary Fungal infections are a major threat to public health as they are becoming increasingly resistant to treatment. Only four classes of antifungals are available,…
Sweet disposition: combatting bacterial infections and antimicrobial resistance with designer proteins that target biofilm matrix carbohydrates
Project Code MRCIIAR25Ca Parmeggiani Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary Microorganisms grow as biofilms on surfaces, from teeth to surgical implants to the lining of lungs. Biofilms are dense cell aggregates embedded in a…
T cell immune modulation during severe bacterial infection
Project Code MRCIIAR25Ca McLaren Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary There is no licenced vaccine against Staphylococcus aureus which produces life-threatening bloodstream infections (“bacteraemia”) and has evolved antibiotic-resistant strains. However, mucosal-associated invariant T (MAIT)…
Systematic Characterisation of Inhibitory Ligands Encoded by Human Cytomegalovirus
Project Code MRCIIAR25Ca Fielding Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary Human cytomegalovirus (HCMV) is the leading infectious cause of congenital birth defects and causes severe disease immunosuppressed individuals. Immune cells, such as T-cell and…
Overcoming β-lactamase-mediated antibiotic resistance by combining biomolecular simulation and experiment
Project Code MRCIIAR25Br Van Der Kamp Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary Antibiotic resistance threatens human health. β-lactamases cause resistance to β-lactams, the most widely used antibiotics. Class C β-lactamases are not well understood,…
Small-Molecule G-Quadruplex (G4) Ligands as Candidate Antibacterials for Resistant Bacteria
Project Code MRCIIAR25Br Spencer Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary Increasing resistance makes developing new antibiotics, that kill bacteria by different mechanisms from existing agents, a public health priority. G-quadruplexes (G4s) are specific nucleotide…
Exploring the modulation of Antioxidant Metabolism to target Adult T-Cell Leukaemia Induced by HTLV-1 Infection
Project Code MRCIIAR25Br Shytaj Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary Human T-lymphotropic virus 1 (HTLV-1) causes lifelong infections and can lead to severe diseases like adult T-cell leukaemia/lymphoma (ATL), with limited treatment options. Our…
Investigating the mechanisms underlying Professional killer cell dysfunction in dengue
Project Code MRCIIAR25Br Rivino Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary Dengue is a mosquito-borne virus infection now affecting half of the world’s population. There is no cure or broadly protective vaccine for dengue. During…