Project Code MRCIIAR25Ex Westra Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary “The spread of antimicrobial resistance (AMR) is a slow-moving pandemic, identified by the WHO as a top-10 threat facing humanity. Staphylococcus aureus is an…
Genetic predisposition to accelerated ageing: targeting telomeres using sex hormone supplementation in chronic lung disease
Project Code MRCIIAR25Ex Scotton Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary Lung fibrosis is a devastating disease which causes 1% of all UK deaths. On average, patients only survive 2-3 years after diagnosis. Ageing is…
The controlled spreading of Wnt receptors determines signalling in the tumour microenvironment
Project Code MRCIIAR25Ex Schlopp Research Theme Cross-CuttingInfection, Immunity, Antimicrobial Resistance and RepairNeuroscience and Mental HealthPopulation Health Sciences Project Summary Download Summary Cells communicate by sending signals that cause receiving cells to change their behaviour. In response to such a signal,…
Plasmids as AMR vectors
Project Code MRCIIAR25Ex Sanders Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary Antimicrobial resistance (AMR) is rising to dangerously high levels causing a global health crisis. To develop strategies to combat AMR, we need to know…
Will climate change worsen the problem of antibiotic resistance?
Project Code MRCIIAR25Ex Padfield Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary Recent studies have shown that levels of antimicrobial resistance (AMR) increase at higher environmental temperatures, but we have limited understanding of the mechanisms causing…
Investigating the impact of epigenetic modifiers, a new treatment for cancer, on fungal pathogens
Project Code MRCIIAR25Ex Neutzmann Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary Fungal pathogens threaten our health and kill over a million patients worldwide. In this project, we will deploy cutting-edge epigenetics research and medical microbiology…
Uncovering new genetic mechanisms of beta-cell autoimmunity to better understand type 1 diabetes
Project Code MRCIIAR25Ex Johnson Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary This project uses a unique collection of samples from people with diabetes to address a fundamental question: What are the genetic mechanisms underpinning beta-cell…
Developing new therapies against the most dangerous antibiotic resistant bacteria
Project Code MRCIIAR25Ex Harmer Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary Antimicrobial resistance is an increasing societal issue, contributing to ~5,000,000 deaths in 2019. The highest priority bacteria are the ESKAPE pathogens that account for…
Investigating oxygenated sterols and lipids in tuberculosis (TB) infection: human’s friend and pathogen’s foe?
Project Code MRCIIAR25Ex Borah Slater Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary “Tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) is a devastating infectious disease causing over one million human deaths every year. We urgently need…
Neonatal Sepsis Detection Automation for Neonatal Intensive Care Units.
Project Code MRCIIAR25Ca Woolley Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary Sepsis is a leading cause of death in infants, particularly in Neonatal Intensive Care Units (NICUs). Early detection is crucial for improving recovery chances.…