Phenotypic and epigenetic analyses of Foetal Alcohol Spectrum Disorder (FASD) in the zebrafish model and human patients

Project Code

MRCPHS26Ex Kudoh

Project Type

Wet lab

Research Theme

Population Health Science

Project Summary Download

Summary

Foetal Alcohol Spectrum Disorder (FASD) occurs via alcohol consumption in pregnancy with 1-5% frequency in humans, causing distinctive facial features alongside brain development defects. In this interdisciplinary project, we will use the zebrafish embryo as an animal model for FASD and utilise human data with epidemiological approaches, linking phenotype of FASD with epigenetic ‘omic data (DNA methylation). The data will be utilised for improving detection of prenatal alcohol exposure and fetal alcohol spectrum disorder and designing targeted therapies to improve outcomes.

Lead Supervisor

Dr Tetsuhiro Kudoh

Lead Supervisor Email

t.kudoh@exeter.ac.uk

University Affiliation

Exeter