Project Code
MRCIIAR26Ex Yvon-Durocher
Project Type
Wet lab
Research Theme
Infection, Immunity, Antimicrobial Resistance and Repair
Project Summary Download
Summary
Periodic episodes of high temperature associated with global climate change may be driving changes in the host range of pathogens, potentially enabling high temperature adapted fungi to make host jumps into human and warm-blooded animals. In this project we will explore how and whether the recently emerged drug-resistant fungal pathogen Candida auris, (now renamed Candidozyma auris) has adapted to rising temperatures. We will compare human fungal pathogens of the Candida and related genera for their thermal tolerance profiles and use serial in vitro adaptation experiments to assess the physiological traits that correlate with thermal adaptation.
Lead Supervisor
Professor Gabriel Yvon-Durocher
Lead Supervisor Email
University Affiliation
Exeter