Project Code
MRCPHS26Ex Yang
Project Type
Wet lab
Research Theme
Population Health Science
Project Summary Download
Summary
A hallmark of type 1 diabetes is elevated blood glucose levels caused by autoimmune destruction of the insulin-producing beta-cells. The existence of remnant beta-cells in patients with type 1 diabetes suggests that we could harness these cells to reverse the disease. This treatment would require strategies to expand the residual beta-cell pool, improve beta-cell functionality, and cloak beta-cells from further autoimmune attack. In this project we will explore the impact of pancreas innervation on beta-cell regeneration and the underlying mechanisms by designing new biologics with generative AI tools and using them to fine-tune the kinetics of endogenous galanin neuropeptide signalling.
Lead Supervisor
Dr Yu Hsuan Carol Yang
Lead Supervisor Email
University Affiliation
Exeter