Project Code
MRCNMH26Ex Piers
Project Type
Wet lab
Research Theme
Neuroscience and Mental Health
Project Summary Download
Summary
Genetic variants in TREM2 and PLCG2 alter microglial responses in Alzheimer’s disease, but the consequences on neurons remain unclear. This project will use cutting-edge human stem cell models to compare microglia carrying pathogenic versus protective variants, to understand how altered gene regulation affects microglial states and influences neuronal health. The student will combine transcriptomics and functional co-culture assays to uncover how microglia shape neural circuits in disease. This interdisciplinary project offers training in stem cell biology, neuroimmunology, functional neuroscience, and computational biology within a vibrant cross-institutional environment.
Lead Supervisor
Dr Thomas Piers
Lead Supervisor Email
University Affiliation
Exeter