Project Code
MRCIIAR26Br Cadby
Project Type
Wet lab
Research Theme
Infection, Immunity, Antimicrobial Resistance and Repair
Project Summary Download
Summary
In this PhD you will use molecular and protein biochemistry approaches to understand how Short Linear Motif (SLiM) containing virulence factors contribute to infection by the tick-borne pathogens, Anaplasma, Ehrlichia, and their relatives. You will work at the molecular scale at the host-pathogen interface, uncovering the targets of these virulence factors, how their interactions with host cell components remodels their biology to favour pathogen proliferation. Ultimately, you will uncover novel biology andexploit this information for proof-of-concept development of novel anti-infectives to combat tick-borne disease and tackle antimicrobial resistance.
Lead Supervisor
Dr Ian Cadby
Lead Supervisor Email
University Affiliation
Bristol