Project Code MRCIIAR26Ex Nuetzmann Project Type Wet lab Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary Microbial infections threaten our health and kill millions worldwide. In this project, we will deploy cutting edge biochemistry, genomics, and…
Will climate change worsen the problem of antibiotic resistance?
Project Code MRCIIAR26Ex Padfield Project Type Wet lab Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary Recent studies have shown that levels of antimicrobial resistance (AMR) increase at higher environmental temperatures, but we have limited understanding…
Establishing a humanised zebrafish model for studying the genetic resilience in Neurofibromatosis Type 1 (NF1)
Project Code MRCIIAR26Ex Scholpp Project Type Wet lab Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary This PhD project explores the phenomenon of “genetic resilience” in the context of Malignant Peripheral Nerve Sheath Tumours (MPNSTs), aggressive…
Developing CRISPR-Cas antimicrobials to tackle antibiotic resistance spread in Klebsiella pneumoniae
Project Code MRCIIAR26Ex van Houte Project Type Wet lab Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary Antimicrobial resistance (AMR) poses a major threat to human health, which is for a large part driven by plasmids…
Novel phage-based therapeutics against drug-resistant bacteria
Project Code MRCIIAR26Ex Westra Project Type Wet lab Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary Antibiotic-resistant Pseudomonas aeruginosa is a major global health threat, causing infections that are increasingly difficult to treat. This project will…
Quantifying Rapid Evolution of Thermal Tolerance in the Novel Pathogenic Fungus Candida auris (Candidozyma auris)
Project Code MRCIIAR26Ex Yvon-Durocher Project Type Wet lab Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary Periodic episodes of high temperature associated with global climate change may be driving changes in the host range of pathogens,…
Developing phage therapy solutions for Staphylococcus aureus
Project Code MRCIIAR25Ex Westra Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary “The spread of antimicrobial resistance (AMR) is a slow-moving pandemic, identified by the WHO as a top-10 threat facing humanity. Staphylococcus aureus is an…
Genetic predisposition to accelerated ageing: targeting telomeres using sex hormone supplementation in chronic lung disease
Project Code MRCIIAR25Ex Scotton Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary Lung fibrosis is a devastating disease which causes 1% of all UK deaths. On average, patients only survive 2-3 years after diagnosis. Ageing is…
The controlled spreading of Wnt receptors determines signalling in the tumour microenvironment
Project Code MRCIIAR25Ex Schlopp Research Theme Cross-CuttingInfection, Immunity, Antimicrobial Resistance and RepairNeuroscience and Mental HealthPopulation Health Sciences Project Summary Download Summary Cells communicate by sending signals that cause receiving cells to change their behaviour. In response to such a signal,…
Plasmids as AMR vectors
Project Code MRCIIAR25Ex Sanders Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary Antimicrobial resistance (AMR) is rising to dangerously high levels causing a global health crisis. To develop strategies to combat AMR, we need to know…