Project Code IIAR27Ca Stanton Project Type Wet lab Research Theme Infection, Immunity, and Antimicrobial Resistance Project Summary Download Summary Worldwide, viruses that transmit to humans from biting insects account for ~17% of infectious diseases and ~700,000 deaths/yr, with ~4 billion…
Cracking the Host-Pathogen Metabolic Code in Tuberculosis: Discovering New Therapeutic Strategies
Project Code IIAR27Ex Borah Slater Project Type Wet lab Research Theme Infection, Immunity, and Antimicrobial Resistance Project Summary Download Summary Tuberculosis (TB) remains one of the world’s leading infectious killers, with the urgent need for new treatments. This exciting PhD…
Phage Power: Optimising Treatments for Bacterial Co-Infections
Project Code IIAR27Ex Castledine Project Type Wet lab Research Theme Infection, Immunity, and Antimicrobial Resistance Project Summary Download Summary As antibiotic resistance threatens modern medicine, phage therapy is emerging as a powerful new weapon against bacterial infections. These naturally occurring…
How does temperature shape selection for resistance across different antibiotics, strains, and species
Project Code IIAR27Ex Padfield Project Type Wet lab Research Theme Infection, Immunity, and Antimicrobial Resistance Project Summary Download Summary Climate warming is linked to rising antimicrobial resistance (AMR), but the biological mechanisms remain poorly understood. This project asks how temperature…
Developing CRISPR-Cas antimicrobials to tackle antibiotic resistance spread in Klebsiella pneumoniae
Project Code IIAR27Ex van Houte Project Type Wet lab Research Theme Infection, Immunity, and Antimicrobial Resistance Project Summary Download Summary Antimicrobial resistance (AMR) poses a major threat to human health, which is for a large part driven by plasmids (mobile…
How pathogens emerge: integrating large language models with comparative genomics to uncover the zoonotic potential of bacteria
Project Code IIAR27Ex Vos Project Type Dry lab Research Theme Infection, Immunity, and Antimicrobial Resistance Project Summary Download Summary Most emerging bacterial pathogens originate from animal hosts (are ‘zoonotic’), yet it is hard to predict which pathogen species are likely…
Bacterial pathogen evolution during antibiotic-phage combination treatment
Project Code IIAR27Ex Westra Project Type Wet lab Research Theme Infection, Immunity, and Antimicrobial Resistance Project Summary Download Summary Antimicrobial resistance is a major threat to modern medicine, and bacteriophage therapy is a promising route to treat drug-resistant infections. Yet…
Decoding the Cellular Origin of Barrett’s Metaplasia Using Microlasers and Lab-on-a-Chip Technologies
Project Code MRCIIAR26Ba Caixeiro Project Type Wet lab Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary Barrett’s Metaplasia (BM), the only known precursor to oesophageal adenocarcinoma, arises from chronic acid reflux. It involves the transformation of…
Co-evolution of bacteriophage within bacterial microbiomes and development of phage therapies
Project Code MRCIIAR26Ba Jones Project Type Wet lab Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary Viruses that infect and kill bacteria (bacteriophage) are promising alternatives to antibiotics and could contribute to controlling antibiotic resistant pathogens.…
A covalent phage display approach to identify complement-targeted autoimmune therapeutics
Project Code MRCIIAR26Ba Lovell Project Type Wet lab Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary Complement is an ancient, conserved system vital for defence against pathogens and maintaining tissue homeostasis. However, dysregulation can cause damage…