Project Code
IIAR27Ex van Houte
Project Type
Wet lab
Research Theme
Infection, Immunity, and Antimicrobial Resistance
Project Summary Download
Summary
Antimicrobial resistance (AMR) poses a major threat to human health, which is for a large part driven by plasmids (mobile pieces of DNA) that facilitate AMR gene spread between bacteria. In this project you will develop new tools based on CRISPR-Cas to stop the spread of AMRcarrying plasmids in the important pathogen Klebsiella pneumoniae. Proof-of-concept work shows that this is theoretically possible, but challenges remain in discerning drivers of plasmid competition. This interdisciplinary project integrates microbiology, genomics, and synthetic biology to tackle one of the most urgent challenges in infectious disease, providing training in leading-edge approaches with real-world impact.
Can the project be completed part time?
Yes
Lead Supervisor
Professor Stineke van Houte
Lead Supervisor Email
University Affiliation
University of Exeter
