Project Code MRCIIAR25Ex Padfield Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary Recent studies have shown that levels of antimicrobial resistance (AMR) increase at higher environmental temperatures, but we have limited understanding of the mechanisms causing…
Investigating the impact of epigenetic modifiers, a new treatment for cancer, on fungal pathogens
Project Code MRCIIAR25Ex Neutzmann Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary Fungal pathogens threaten our health and kill over a million patients worldwide. In this project, we will deploy cutting-edge epigenetics research and medical microbiology…
Uncovering new genetic mechanisms of beta-cell autoimmunity to better understand type 1 diabetes
Project Code MRCIIAR25Ex Johnson Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary This project uses a unique collection of samples from people with diabetes to address a fundamental question: What are the genetic mechanisms underpinning beta-cell…
Developing new therapies against the most dangerous antibiotic resistant bacteria
Project Code MRCIIAR25Ex Harmer Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary Antimicrobial resistance is an increasing societal issue, contributing to ~5,000,000 deaths in 2019. The highest priority bacteria are the ESKAPE pathogens that account for…
Investigating oxygenated sterols and lipids in tuberculosis (TB) infection: human’s friend and pathogen’s foe?
Project Code MRCIIAR25Ex Borah Slater Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary “Tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) is a devastating infectious disease causing over one million human deaths every year. We urgently need…
Neonatal Sepsis Detection Automation for Neonatal Intensive Care Units.
Project Code MRCIIAR25Ca Woolley Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary Sepsis is a leading cause of death in infants, particularly in Neonatal Intensive Care Units (NICUs). Early detection is crucial for improving recovery chances.…
Enhancing Immunological Control of SARS-CoV-2
Project Code MRCIIAR25Ca Stanton Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary Neutralizing antibodies are key to preventing transmission of SARS-CoV-2, however the virus can rapidly mutate to avoid these. Furthermore, once infected, neutralizing antibodies cannot…
New antibiotics to kill “Superbugs” by stopping them from dividing
Project Code MRCIIAR25Ca Serpi Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary While antibiotics have revolutionised the landscape of medicine saving millions of lives, their misuse has also resulted in the rise of “Superbugs”, which are…
Design, synthesis and biological evaluation of molecules to tackle invasive fungal infections
Project Code MRCIIAR25Ca Pertusati Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary Fungal infections are a major threat to public health as they are becoming increasingly resistant to treatment. Only four classes of antifungals are available,…
Sweet disposition: combatting bacterial infections and antimicrobial resistance with designer proteins that target biofilm matrix carbohydrates
Project Code MRCIIAR25Ca Parmeggiani Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary Microorganisms grow as biofilms on surfaces, from teeth to surgical implants to the lining of lungs. Biofilms are dense cell aggregates embedded in a…