Project Code
MRCNMH26Br Dick
Project Type
Wet lab
Research Theme
Neuroscience and Mental Health
Project Summary Download
Summary
Age-related macular degeneration (AMD) is the leading cause of blindness in the developed world. Projected to affect 288M by 2040, there are no therapeutic options for the common form of AMD (dry AMD) approved in the UK. Emerging research highlights common disease pathways between AMD and a group of inherited metabolic diseases, lysosomal storage disorders (LSD), with vision loss a common early symptom in many LSDs. This project will draw on knowledge gained from the study of LSDs to investigate key aspects of lysosomal health in AMD models, and explore the potential for repurposing LSD approved therapeutics to treat AMD.
Lead Supervisor
Professor Andrew Dick
Lead Supervisor Email
University Affiliation
Bristol