Project Code
MRCNMH26Br Hodge
Project Type
Wet lab
Research Theme
Neuroscience and Mental Health
Project Summary Download
Summary
CASK is a synaptic scaffolding molecule and kinase with mutations causing brain and behavioural defects including severe learning difficulties, movement and sleep disruption as well as epilepsy. You will be trained to generate fly and cellular models of CASK disease characterising them using cutting-edge molecular genetics, bioinformatics, behaviour, electrophysiology, optogenetics, imaging, modelling and pharmacology. You will work with our clinical team and patient groups generating human CASK clinical and molecular data identifying new mutations and phenotypes which you can then study in your pre-clinical models allowing you to test novel genetic and pharmacological treatments, prior to follow-on clinical trials.
Lead Supervisor
Professor James Hodge
Lead Supervisor Email
University Affiliation
Bristol