Project Code
MRCNMH25Ca Davies
Research Theme
Neuroscience & Mental Health
Project Summary Download
Summary
In mice and humans loss-of-function of the steroid sulfatase (STS) enzyme results in inattention but enhanced motor response inhibition; we aim to understand the neurobiology underlying this dissociation using a new mouse model. The project will develop cutting-edge research skills in behavioural neuroscience and electrophysiology, will have direct clinical relevance to X-linked ichthyosis (STS deficiency), and will signpost mechanisms associated with Attention Deficit Hyperactivity Disorder subtypes.
Keywords: Astrocyte, basal ganglia, globus pallidus, Stop Signal Reaction Time Task (SSRT), subthalamic nucleus
Lead Supervisor
Dr William Davies
Lead Supervisor Email
daviesw4@cardiff.ac.uk
University Affiliation
Cardiff