Project Code
MRCIIAR25Br Shytaj
Research Theme
Infection, Immunity, Antimicrobial Resistance and Repair
Project Summary Download
Summary
Human T-lymphotropic virus 1 (HTLV-1) causes lifelong infections and can lead to severe diseases like adult T-cell leukaemia/lymphoma (ATL), with limited treatment options. Our preliminary evidence shows HTLV-1 disrupts cellular metabolism, increasing oxidative stress to support rapid cell multiplication, potentially making infected cells reliant on antioxidant responses for their survival. This project aims to study the interplay between antioxidant metabolism and cell fate in the context of ATL. The final aim of the project is identify key antioxidant pathways crucial for ATL survival and test potential therapies in cell models to selectively eliminate infected tumor cells.
Lead Supervisor
Dr Iart Luca Shytaj
Lead Supervisor Email
luca.shytaj@bristol.ac.uk
University Affiliation
Bristol