Project Code
MRCIIAR25Ex Harmer
Research Theme
Infection, Immunity, Antimicrobial Resistance and Repair
Project Summary Download
Summary
Antimicrobial resistance is an increasing societal issue, contributing to ~5,000,000 deaths in 2019. The highest priority bacteria are the ESKAPE pathogens that account for over half this mortality and morbidity. This project will contribute to fighting antimicrobial resistance by developing new high-throughput in vivo ESKAPE pathogen infection models in the wax moth Galleria mellonella. These will be used to test resistant clinical isolates with our novel compounds that make bacteria more susceptible to conventional antibiotics and facilitate further development of the compounds. The project will accelerate the development of our compounds and provide new in vivo models for antimicrobial discovery.
Lead Supervisor
Professor Nicholas Harmer
Lead Supervisor Email
N.J.Harmer@exeter.ac.uk
University Affiliation
Exeter