Project Code
MRCNMH25Ba Nikolaou
Research Theme
Neuroscience and Mental Health
Project Summary Download
Summary
Alzheimer’s disease (AD) is the leading cause of dementia characterized by memory loss and cognitive decline. Whilst cognitive decline in dementia is a progressive process affecting various aspects of mental functioning, an understanding of the early changes in the brain could provide the means for early detection, effective treatment, and the necessary support to individuals and their families. This project will utilise experimental approaches in human induced pluripotent stem cells (hiPSCs) and zebrafish to identify and characterise the early neuronal network dysfunctions caused by AD causative gene mutations, which could lead to large-scale small molecule screens to identify novel therapeutics.
Lead Supervisor
Dr Nikolas Nikolaou
Lead Supervisor Email
nn456@bath.ac.uk
University Affiliation
Bath