Project Code
MRCNMH25Br Mellor
Research Theme
Neuroscience & Mental Health
Project Summary Download
Summary
Genetic risk factors for schizophrenia are clustered around genes that regulate synaptic function and adaptation, indicating common disrupted biological processes that underpin the cognitive impairments in memory and flexible learning. We have revealed how loss of function in one of these genes (Dlg2) perturbs core features of synaptic signalling and adaptation and are investigating others including Grin2A and Gria3. In this project, we will uncover how these mechanisms lead to abnormal cognition by directly measuring neuronal adaptations during tasks demanding cognitive flexibility. We will then test mechanisms to rescue cognition including drugs that target neuromodulator systems.
Lead Supervisor
Professor Jack Mellor
Lead Supervisor Email
jack.mellor@bristol.ac.uk
University Affiliation
Bristol