Project Code
MRCPHS25Ex Revuelta Iniesta
Research Theme
Population Health Sciences
Project Summary Download
Summary
Survivors of childhood acute lymphoblastic leukaemia (ALL) experience premature frailty and muscle atrophy. Muscle protein synthesis is crucial for muscle growth and is mainly stimulated by physical activity and dietary protein. Since dietary protein intakes in ALL survivors do not differ from the general population, it is suggested that the observed muscle atrophy is caused by an inability of muscle growth to respond normally to dietary stimuli, termed anabolic resistance. This PhD will mechanistically explore if anabolic resistance underlies frailty in ALL survivors in response to diet, and design tailored dietary and exercise interventions to promote muscle growth.
Lead Supervisor
Dr Raquel Revuelta Iniesta
Lead Supervisor Email
r.revuelta-iniesta@exeter.ac.uk
University Affiliation
Exeter