Project Code
MRCNMH26Br Collinson
Project Type
It is both a wet and a dry project.
Research Theme
Neuroscience and Mental Health
Project Summary Download
Summary
Mitochondria are vital for energy production, cell function and homeostasis, and thereby health. This project explores how the protein PINK1, key to mitochondrial quality-control, is imported into mitochondria and how its misdirection contributes to early-onset Parkinson’s disease. We have discovered a new pathway for PINK1 import, and show that its structure influences its fate and function. Using advanced biochemical, biophysical, and computational tools, the project will investigate how PINK1 variants associated with Parkinson’s affect mitochondrial function, and progression of disease. This interdisciplinary project offers exciting opportunities to uncover novel mechanisms of neuro-degeneration and gain hands-on experience with cutting-edge research techniques.
Lead Supervisor
Professor Ian Collinson
Lead Supervisor Email
University Affiliation
Bristol