Project Code
MRCNMH26Ex Flynn
Project Type
The project is primarily wet-lab based, with a dry-lab component in Years 2 and 3.
Research Theme
Neuroscience and Mental Health
Project Summary Download
Summary
Genetic variants in the CTCF gene, which encodes a protein that organizes DNA, cause neurodevelopmental disorders including intellectual disability and autism. However, the mechanisms responsible are not well understood. This project will use human stem cell models to investigate how CTCF variants disrupt DNA organization controls brain development. You will examine whether (i) binding of CTCF to DNA, (ii) chromatin structure and function and (iii) neural differentiation and brain organoid development are affected. You will also explore approaches to rescue the developmental defects. The student will gain valuable training in stem cell culture, genomics, and bioinformatic analyses of large datasets.
Lead Supervisor
Dr Sean Flynn
Lead Supervisor Email
University Affiliation
Exeter