Project Code NMH27Ba Halligan Project Type Dry lab Research Theme Neuroscience and Mental Health Project Summary Download Summary Young people exposed to adversity are at risk of a range of mental health problems including anxiety, depression and conduct-related problems, making…
Parental transmission of substance use: exploring mechanisms and informing intervention
Project Code NMH27Ba Hines Project Type Dry lab Research Theme Neuroscience and Mental Health Project Summary Download Summary Reducing substance use is a key goal within public health. Recent work has shown that a strong predictor of adolescent substance use…
Stress reactivity and mental health in young people; how do we measure it, and can we fix it when it goes wrong?
Project Code NMH27Ba Jacobsen Project Type Wet lab Research Theme Neuroscience and Mental Health Project Summary Download Summary How a person reacts to stressful things in everyday life is known as ‘stress reactivity’. This includes how a person reacts in…
Beyond Pain Intensity: Ecological Measurement and Neurostimulation of Pain-Related Motor Interference
Project Code NMH27Ba Khatibi Project Type Other Research Theme Neuroscience and Mental Health Project Summary Download Summary This project will develop and validate an ecologically meaningful measure of pain-related interference with motor function. Rather than relying on simple laboratory tasks…
The brain-skin link in psychosis: uncovering shared biology and new treatment targets
Project Code NMH27Ba Lancaster Project Type Dry lab Research Theme Neuroscience and Mental Health Project Summary Download Summary Severe mental illnesses (e.g. schizophrenia/bipolar disorder) affect the whole body, not just the brain – and share genetic links with inflammatory conditions,…
Decoding Neurodevelopmental Disorders: From Patient Variants to Disease Mechanisms
Project Code NMH27Ba Licchesi Project Type Wet lab Research Theme Neuroscience and Mental Health Project Summary Download Summary Rare genetic variants are a major cause of neurodevelopmental disorders, including autism, epilepsy and intellectual disability, yet the underlying disease mechanisms remain…
Boosting the Brain Cell Recycling System: Peptide Activation of TFEB in Neurodegeneration
Project Code NMH27Ba Mason Project Type Other Research Theme Neuroscience and Mental Health Project Summary Download Summary Many neurodegenerative diseases, including Parkinson’s disease, involve failure of the cell’s waste-clearance system, allowing damaged proteins and organelles to accumulate. TFEB is a…
Anxiety-Related Attention Bias in Everyday Situations: Mechanisms and VR-Based Modification
Project Code NMH27Ba Voinescu Project Type Dry lab Research Theme Neuroscience and Mental Health Project Summary Download Summary Anxiety can distort how we pay attention, making us overly focused on potential threats and less able to respond flexibly to what…
Combining epigenetics and neuroimaging to predict mental health traits across child development
Project Code NMH27Ba Walton Project Type Dry lab Research Theme Neuroscience and Mental Health Project Summary Download Summary Epigenetic and structural brain alterations have been separately linked to neurodevelopmental and psychiatric conditions, but little is known about their combined impact…
You snooze, you win: harnessing hibernation biology for organ protection
Project Code NMH27Br Ambler Project Type Wet lab Research Theme Neuroscience and Mental Health Project Summary Download Summary Hibernating animals survive with barely-beating hearts and minimal oxygen. What if we could borrow that trick for critically ill patients? We’ve found…