Project Code
MRCIIAR26Ca Raby
Project Type
Wet lab
Research Theme
Infection, Immunity, Antimicrobial Resistance and Repair
Project Summary Download
Summary
People with chronic kidney disease (CKD) are more vulnerable to infections, in part because their immune systems don’t function properly. One reason is that chronic inflammation in CKD leads to constant low-level activation of immune cells, which over time may exhaust the body’s defences. We have identified certain molecules called Damage-Associated Molecular Patterns (DAMPs) that are released when tissues are damaged in CKD, and found that they trigger immune sensors to cause chronic inflammation. We now aim to evaluate whether blocking the activity of certain DAMPs could prevent immune exhaustion in CKD patients and help them fight infections better.
Lead Supervisor
Dr Anne-Catherine Raby
Lead Supervisor Email
University Affiliation
Cardiff