Communication Breakdown: Using human assembloid models to understand disruption of neuron-glia interactions in ALS.

Project Code

MRCNMH26Ex Bhinge

Project Type

Primarily wet-lab with a strong computational component.

Research Theme

Neuroscience and Mental Health

Project Summary Download

Summary

ALS is a devastating neurological disease with no cure, and we urgently need new ways to understand and treat it. This exciting PhD project combines cutting-edge stem cell technology, 3D brain cell models, and advanced genomic analysis to explore how nerve cells and support cells interact in health and disease. You’ll model a key ALS feature seen in most patients and use high-resolution single-cell techniques and drug screening to uncover new disease mechanisms and drug candidates. This highly interdisciplinary and collaborative project offers exceptional training in neuroscience, genomics, bioinformatics and translational research.

Lead Supervisor

Dr Akshay Bhinge

Lead Supervisor Email

A.Bhinge@exeter.ac.uk

University Affiliation

Exeter