Effect of Alzheimer’s disease risk variants on microglial cell state transitions in response to pathology

Project Code

MRCNMH24Ex Piers

Research Theme

Neuroscience and Mental Health

Full Project Description

Please download the below document for a full project description and to see the full supervisory team.


Microglia are strongly linked to Alzheimer’s disease (AD), supported by significant cell-type specific genetic association. However, there is a substantial gap in our understanding of how genetic variation affect microglial response to pathology. This project will use culture models to uncover the mechanisms associated with microglial activation states using a multidisciplinary approach including microscopy, electrophysiology, epigenetics, and bioinformatics.

Lead Supervisor

Dr Thomas Piers

Lead Supervisor Email


University Affiliation