Epigenetic profiling in Parkinson’s disease: novel mechanisms and drug targets

Project Code

MRCNMH26Ex Migdalska-Richards

Project Type

A particular strength of this project is that it combines both wet-lab work (microRNA profiling, cell culturing and transfection) and bioinformatics, allowing the student to acquire a valuable combination of skills that will be excellent preparation for their future career, be it in academia or elsewhere.

Research Theme

Neuroscience and Mental Health

Project Summary Download

Summary

During this PhD, you will be one of the very first people to study the epigenetics of Parkinson’s disease. You will determine and functionally evaluate the first-ever comprehensive microRNA profile in different brain regions of individuals with Parkinson’s disease. This will involve combining the exciting areas of epigenetics, bioinformatics and molecular biology. This work will improve mechanistic understanding and suggest novel drug targets for this devastating condition.

Lead Supervisor

Dr Anna Migdalska-Richards

Lead Supervisor Email

a.migdalska-richards@exeter.ac.uk

University Affiliation

Exeter