From Survivor Blood to Curing Cancer

Project Code

MRCIIAR26Ca Sewell

Project Type

Wet lab

Research Theme

Infection, Immunity, Antimicrobial Resistance and Repair

Project Summary Download

Summary

How do rare patients cure their own cancer?
Some individuals with advanced cancers achieve complete remission, defying the odds without standard treatment. This project will investigate the natural T-cells responsible for these outcomes. Working with unique samples from exceptional survivors, you will explore how these T-cells recognise and eliminate cancer, sometimes across multiple tumour types and unrelated individuals. Using advanced T-cell engineering and CRISPR screening, you will uncover new cancer-specific targets with genuine therapeutic potential. This is a rare opportunity to help decode natural immunity to cancer and contribute to the development of the next generation of immunotherapies.

Lead Supervisor

Professor Andrew Sewell

Lead Supervisor Email

sewellak@cardiff.ac.uk

University Affiliation

Cardiff