Project Code
MRCIIAR26Ca Stanton
Project Type
Wet lab
Research Theme
Infection, Immunity, Antimicrobial Resistance and Repair
Project Summary Download
Summary
Humans exhibit variable outcomes when infected with identical pathogens for multiple reasons. We have discovered a new mechanism that may underpin this, in which a common virus (Cytomegalovirus) expresses proteins to ‘turn off’ a key part of cellular immunity. However different virus strains are able to do this with differential effectiveness. This PhD will use in vitro analysis and clinical cohorts to understand how these different abilities function, how they alter the capacity of the human immune system to control infection, and whether they can be used to predict disease severity.
Lead Supervisor
Professor Richard Stanton
Lead Supervisor Email
University Affiliation
Cardiff