Project Code
MRCNMH26Ca Ngo
Project Type
Wet lab
Research Theme
Neuroscience and Mental Health
Project Summary Download
Summary
Neurodevelopmental disorders (NDDs) like autism and ADHD affect millions, yet the underlying causes remain unclear. This PhD project investigates how mutations in the gene UPF3B, linked to NDDs, impair DNA repair in neurons. Using advanced techniques including CRISPR gene-editing, biochemical assay, nanopore DNA sequencing, and stem cell-derived neurons, the student will explore a novel disorder mechanism at the intersection of genome stability and brain development. The project offers multidisciplinary training in genetics, biochemistry, genomics, neuroscience, and bioinformatics. This work could contribute to improved diagnosis and understanding of NDDs, making a real-world impact on one of today’s most pressing health challenges.
Lead Supervisor
Dr Greg Ngo
Lead Supervisor Email
University Affiliation
Cardiff