Project Code
MRCNMH24Br Hodge
Research Theme
Neuroscience and Mental Health
Full Project Description
Please download the below document for a full project description and to see the full supervisory team.
Summary
Variations in the CACNA1C gene are strongly associated with risk of neuropsychiatric conditions such as epilepsy and psychoses, and specific CACNA1C gain-of-function mutations cause Timothy syndrome. To better understand the role of CACNA1C in disease mechanisms the project will combine functional and behavioural analyses of genetic CACNA1C mutant fly models with computational modelling based on functional and molecular data from human tissue, rodent and fly models.
Lead Supervisor
Professor James Hodge
Lead Supervisor Email
james.hodge@bristol.ac.uk
University Affiliation
Bristol