Modelling the role of L-type voltage-gated calcium channels (CACNA1C) signalling in epilepsy and mental health

Project Code

MRCNMH24Br Hodge

Research Theme

Neuroscience and Mental Health

Full Project Description

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Variations in the CACNA1C gene are strongly associated with risk of neuropsychiatric conditions such as epilepsy and psychoses, and specific CACNA1C gain-of-function mutations cause Timothy syndrome. To better understand the role of CACNA1C in disease mechanisms the project will combine functional and behavioural analyses of genetic CACNA1C mutant fly models with computational modelling based on functional and molecular data from human tissue, rodent and fly models.

Lead Supervisor

Professor James Hodge

Lead Supervisor Email

University Affiliation