Neuroscience and Mental Health
Full Project Description
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Variations in the CACNA1C gene are strongly associated with risk of neuropsychiatric conditions such as epilepsy and psychoses, and specific CACNA1C gain-of-function mutations cause Timothy syndrome. To better understand the role of CACNA1C in disease mechanisms the project will combine functional and behavioural analyses of genetic CACNA1C mutant fly models with computational modelling based on functional and molecular data from human tissue, rodent and fly models.
Professor James Hodge
Lead Supervisor Email