Project Code MRCPHS25Ex Revuelta Iniesta Research Theme Population Health Sciences Project Summary Download Summary Survivors of childhood acute lymphoblastic leukaemia (ALL) experience premature frailty and muscle atrophy. Muscle protein synthesis is crucial for muscle growth and is mainly stimulated by…
Development of guidelines and resources to encourage and support exercise in pregnant women with pre-existing Type 2 Diabetes
Project Code MRCPHS25Ex Pulsford Research Theme Population Health Sciences Project Summary Download Summary A physically active pregnancy including regular exercise reduces pregnancy complications in women with pre-existing type 2 diabetes (T2D) and supports the health of mother and baby, but…
An integrated hydro-epidemiological approach to prevent and mitigate water-related zoonotic diseases leveraging nature-based solutions
Project Code MRCPHS25Ex Panici Research Theme Population Health Sciences Project Summary Download Summary Waterborne zoonotic diseases, such as Cryptosporidium, E.coli, and Leptospira are a serious threat to drinking water safety, especially in rural, farm-dominated lands. Nature-based solutions (NbS) in hydrology…
Using big data to explore how hot flushes and poor sleep contribute to women’s health after menopause
Project Code MRCPHS25Ex Murray Research Theme Population Health Sciences Project Summary Download Summary Vasomotor symptoms (hot flushes and night sweats) and sleep problems are commonly reported by women going through the menopause. Their relationship is unclear but both are linked…
Exploring the feasibility and efficacy of an aerobic exercise intervention in improving dietary self-regulation in adolescents and young adults
Project Code MRCPHS25Ex Lowe Research Theme Population Health Sciences Project Summary Download Summary Adolescents are the largest consumers of ultra-processed calorie-dense foods of any other age group. This is of concern, as diet quality can impact the development of the…
Understanding genetic modifiers of obesity and metabolic disease
Project Code MRCPHS25Ex Hawkes Research Theme Population Health Sciences Project Summary Download Summary A person’s health is influenced by their socioeconomic status, smoking and other behavioural and environmental factors, as well as their genetic make-up. Some genetic variants directly affect…
Combining technologies to elucidate the epigenome’s impact on health and disease
Project Code MRCPHS25Ex Hannon Research Theme Population Health Sciences Project Summary Download Summary The epigenome’s dynamic nature and it’s responsiveness to environmental changes make it particularly attractive in the study of health and disease. This interest has resulted in various…
Integrative analysis of whole genomes and transcriptomes from multiple cell types in rare disease patients
Project Code MRCPHS25Ex Frontini Research Theme Population Health Sciences Project Summary Download Summary Comprehensive genetic analysis using whole genome sequencing (WGS) still fails to identify the genetic cause of diseases in about 50% of patients with rare diseases. To increase…
Unveiling the Biomechanics of Diabetic Foot Ulcers: Identifying Critical Foot Load Profiles for Prevention and Treatment
Project Code MRCPHS25Ex Akrami Research Theme Population Health Sciences Project Summary Download Summary Diabetic foot issues pose significant challenges for patients and healthcare providers. Current evaluation methods are costly, invasive, and subjective. This study aims to address these problems by…
Characterising a new neuroimmune pathway to treat Alzheimer’s disease
Project Code MRCNMH25Ex Witton Research Theme Neuroscience & Mental Health Project Summary Download Summary Microglia are brain-resident immune cells. Alongside conventional molecular signals, the latest research suggests that specific patterns of brain activity can control microglia function. We have found…