Investigating the penetrance of cancer susceptibility genes in a population cohort and the influences of family history and rare and common genetic modifiers

Project Code

MRCPHS24Ex Jackson

Research Theme

Population Health Sciences

Full Project Description

Please download the below document for a full project description and to see the full supervisory team.


Offering genetic testing only to those with a family history of cancer has led to current evidence on disease risk in carriers of cancer-causing variants being artificially inflated. This project will use large genetic datasets to compare effects of rare cancer-causing variants across groups based on variables such as age, sex, screening and family history in a general population setting. This work will help to inform clinicians how to counsel patients.

Lead Supervisor

Dr Leigh Jackson

Lead Supervisor Email

University Affiliation