Developing computational models of psychosis to explore the impact of schizophrenia-associated CNVs on cortical microcircuitry

Project Code


Research Theme

Neuroscience and Mental Health

Full Project Description

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Breakthroughs in genetics have identified specific CNVs that substantially increase risk for schizophrenia. These CNVs impact NMDA & GABAA receptors, but how this disrupts cortical function is unknown. You will develop computational models that capture changes in NMDA and GABA receptor dynamics in CNV carriers. These models will be applied to existing neuroimaging (MEG) and cognitive data to make novel insights connecting genetics to brain function and cognition.

Lead Supervisor

Dr Alexander Shaw

Lead Supervisor Email

University Affiliation