Project Code MRCIIAR26Ba Caixeiro Project Type Wet lab Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary Barrett’s Metaplasia (BM), the only known precursor to oesophageal adenocarcinoma, arises from chronic acid reflux. It involves the transformation of…
Co-evolution of bacteriophage within bacterial microbiomes and development of phage therapies
Project Code MRCIIAR26Ba Jones Project Type Wet lab Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary Viruses that infect and kill bacteria (bacteriophage) are promising alternatives to antibiotics and could contribute to controlling antibiotic resistant pathogens.…
A covalent phage display approach to identify complement-targeted autoimmune therapeutics
Project Code MRCIIAR26Ba Lovell Project Type Wet lab Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary Complement is an ancient, conserved system vital for defence against pathogens and maintaining tissue homeostasis. However, dysregulation can cause damage…
Bacterial Hunger Games: Targeting Nutrient Transport for Novel Antibiotic Development
Project Code MRCIIAR26Ba Preston Project Type Wet lab Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary Most current antibiotics are derivatives of previous drugs and resistance adapts quickly to the new derivatives, greatly limiting their useful…
Understanding β-lactam antibiotic action and resistance with developments in dynamic structural biology
Project Code MRCIIAR26Ba Tooke Project Type This project combines both wet and dry lab elements. The primary focus will be on wet-lab methods (enzyme purification, biochemical characterisation of enzymes, structural biology) but will feature dry lab approaches (biomolecular simulation). Research…
Tuning the Innervation Capacity of Regenerative Biomaterials
Project Code MRCIIAR26Br Armstrong Project Type Wet lab Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary Biomaterials can be used to regenerate diseased or damaged tissues. Substantial progress has been made in our understanding of the…
Tackling tick-borne pathogenic bacteria through SLiMs
Project Code MRCIIAR26Br Cadby Project Type Wet lab Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary In this PhD you will use molecular and protein biochemistry approaches to understand how Short Linear Motif (SLiM) containing virulence…
Artificial intelligence to identify antifungal susceptibility in the clinical diagnostic laboratory
Project Code MRCIIAR26Br Dowsey Project Type Wet lab Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary Fungal infections have become a major and growing global health crisis, causing an estimated 3.8 million deaths each year particularly…
Microplastics, big problems: dissecting effects on the immune system and skeletal repair
Project Code MRCIIAR26Br Hammond Project Type Wet lab Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary There is a growing awareness that micro- and nanoplastics, which are increasingly prevalent in our environment, pose risks to human…
Bridging the Gap: Improving Access to Care for people at Risk of Type 1 Diabetes
Project Code MRCIIAR26Br Long Project Type Wet lab Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary A paradigm shift is underway in type 1 diabetes (T1D) treatment. For over a century, T1D has been managed, but…