Project Code NMH27Ex Oguro-Ando Project Type Wet lab Research Theme Neuroscience and Mental Health Project Summary Download Summary How do neurons instruct astrocytes to build the developing brain? This project explores how neuronal signals regulate astrocyte function and how this…
Discovery and functional testing of Alzheimer’s disease risk–resilience pathways in human iPSC microglia
Project Code NMH27Ex Piers Project Type Wet lab Research Theme Neuroscience and Mental Health Project Summary Download Summary Late onset Alzheimer’s disease (LOAD) risk is shaped by microglial genes, particularly the TREM2 signalling axis. The coding mutation TREM2 R47H increases…
Cross-species modelling of rare coding variants associated withschizophrenia
Project Code NMH27Ex Ryu Project Type Wet lab Research Theme Neuroscience and Mental Health Project Summary Download Summary Schizophrenia is a severe psychiatric disorder with debilitating effects on a patient’s quality of life. Because current medications do not work well,…
How sights become signals for learning
Project Code NMH27Ex YZhang Project Type Wet lab Research Theme Neuroscience and Mental Health Project Summary Download Summary How does the brain discover that a sight predicts something important? This project will uncover the neural circuits that transform visual information…
Early-life infection exposure and risk of allergy and lung disease in adulthood
Project Code PHS27Br Hamilton Project Type Other Research Theme Population Health Science Project Summary Download Summary Early-life respiratory infections influence long-term lung health, yet we do not understand why only some children later develop asthma, recurrent infections or reduced lung…
Investigating mechanisms of cell competition in breast cancer susceptibility and early tumour initiation
Project Code PHS27Br Lloyd-Lewis Project Type Wet lab Research Theme Population Health Science Project Summary Download Summary How do cancers grow into space occupied by normal cells? Competition between tumour and non-tumour cells plays an important role, allowing tumour cells…
Decoding the Cellular Origin of Barrett’s Metaplasia Using Microlasers and Lab-on-a-Chip Technologies
Project Code MRCIIAR26Ba Caixeiro Project Type Wet lab Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary Barrett’s Metaplasia (BM), the only known precursor to oesophageal adenocarcinoma, arises from chronic acid reflux. It involves the transformation of…
Co-evolution of bacteriophage within bacterial microbiomes and development of phage therapies
Project Code MRCIIAR26Ba Jones Project Type Wet lab Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary Viruses that infect and kill bacteria (bacteriophage) are promising alternatives to antibiotics and could contribute to controlling antibiotic resistant pathogens.…
A covalent phage display approach to identify complement-targeted autoimmune therapeutics
Project Code MRCIIAR26Ba Lovell Project Type Wet lab Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary Complement is an ancient, conserved system vital for defence against pathogens and maintaining tissue homeostasis. However, dysregulation can cause damage…
Bacterial Hunger Games: Targeting Nutrient Transport for Novel Antibiotic Development
Project Code MRCIIAR26Ba Preston Project Type Wet lab Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary Most current antibiotics are derivatives of previous drugs and resistance adapts quickly to the new derivatives, greatly limiting their useful…