Investigating mechanisms of cell competition in breast cancer susceptibility and early tumour initiation

Project Code

PHS27Br Lloyd-Lewis

Project Type

Wet lab

Research Theme

Population Health Science

Project Summary Download

Summary

How do cancers grow into space occupied by normal cells? Competition between tumour and non-tumour cells plays an important role, allowing tumour cells to eliminate normal cells and grow in their stead. Yet the underlying molecular mechanisms remain unclear. In this interdisciplinary project, the student will investigate mechanisms controlling cell competition, breast tumour initiation and progression through combining advanced methods in genetic epidemiology with labbased cell biology techniques using cancer cell lines, pluripotent stem cells, patient-derived 3D primary organoids and in vivo models.

Can the project be completed part time?

Yes

Lead Supervisor

Dr Bethan Lloyd-Lewis

Lead Supervisor Email

bethan.lloyd-lewis@bristol.ac.uk

University Affiliation

University of Bristol

Back to top ↑