How Neurons Shape Astrocytes: Decoding Cell-to-Cell Communication in Brain Development

Project Code

NMH27Ex Oguro-Ando

Project Type

Wet lab

Research Theme

Neuroscience and Mental Health

Project Summary Download

Summary

How do neurons instruct astrocytes to build the developing brain? This project explores how neuronal signals regulate astrocyte function and how this communication is disrupted in neurodevelopmental disorders. Using a unique combination of mouse models, primary astrocyte culture, transcriptomics, and advanced imaging, you will identify the molecular signals linking neuronal JAKMIP1 dysfunction to altered astrocyte behaviour. Training across the Universities of Exeter, Bristol and Cardiff will provide expertise in molecular neuroscience, glial biology, bioinformatics, and disease modelling. This interdisciplinary project offers an exciting opportunity to uncover fundamental mechanisms of brain development while developing highly transferable research skills.

Can the project be completed part time?

Yes

Lead Supervisor

Dr AsamiOguro-Ando

Lead Supervisor Email

A.Oguro-Ando@exeter.ac.uk

University Affiliation

University of Exeter

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