Project Code NMH27Ca Ngo Project Type Wet lab Research Theme Neuroscience and Mental Health Project Summary Download Summary Neurodevelopmental disorders (NDDs) like autism and ADHD affect millions, yet the underlying causes remain unclear. This PhD project investigates how mutations in…
From Multi-OMICs to mechanism: understanding the links between protein turnover and therapy resistance in glioblastoma stem cells
Project Code NMH27Ca Siebzehnrubl Project Type Other Research Theme Neuroscience and Mental Health Project Summary Download Summary How do glioblastoma stem cells evade therapy and drive tumour recurrence? This project will address this question by investigating how FGF2-FGFR1 signalling regulates…
Silent Architects: Uncovering How Astrocytes Shape Brain Health
Project Code NMH27Ca Smith Project Type Wet lab Research Theme Neuroscience and Mental Health Project Summary Download Summary Astrocytes are central regulators of brain function, controlling neuronal activity, metabolism, extracellular matrix organisation and resilience to disease. However, many astrocyte-enriched genes…
Mapping Cerebellar Network Dysfunction in Episodic Ataxia Using Human Organoids
Project Code NMH27Ca Syed Project Type Wet lab Research Theme Neuroscience and Mental Health Project Summary Download Summary This project investigates how mutations in the KCNA1 gene cause Episodic Ataxia Type 1 (EA1), a rare neurological disorder characterised by impaired…
Pain as neurobiological surprise: Using human brain imaging and animal studies to advance new concepts in persistent pain.
Project Code NMH27Ca Tackley Project Type Other Research Theme Neuroscience and Mental Health Project Summary Download Summary We experience surprise when our best guess about the immediate future turns out to be wrong. This can be dangerous: it might mean…
Cracking the ribosome code of brain development
Project Code NMH27Ex Bernard Project Type Wet lab Research Theme Neuroscience and Mental Health Project Summary Download Summary What if ribosomes carried a code that helps build the brain? Ribosomes are complex molecular structures that play active roles in protein…
Communication Breakdown: Using human 3D bioprinted models to understand disruption of neuron-muscle interactions in ALS
Project Code NMH27Ex Bhinge Project Type Wet lab Research Theme Neuroscience and Mental Health Project Summary Download Summary ALS is a devastating neurological disease with no cure, and we urgently need new ways to understand and treat it. This exciting…
Developing Blood Tests for the Early Detection of Neurodegeneration Following Traumatic Brain Injury
Project Code NMH27Ex Dempster Project Type Wet lab Research Theme Neuroscience and Mental Health Project Summary Download Summary Traumatic brain injury (TBI), including repetitive head impacts during contact sports, increases the risk of developing later-life neurodegenerative diseases such as chronic…
Turning off transcription factors to understand what happens first in neurodevelopmental disorders
Project Code NMH27Ex Flynn Project Type Wet lab Research Theme Neuroscience and Mental Health Project Summary Download Summary What are the first things that go wrong in neurodevelopmental disorders? This project will use human stem cells to grow early brain…
Translational models to predict emotional susceptibility to chronic pain
Project Code NMH27Ex Lawrenson Project Type Wet lab Research Theme Neuroscience and Mental Health Project Summary Download Summary This project aims to investigate how our emotions make individuals susceptible to the experience of pain. By identifying and applying a translational…