Project Code
NMH27Ca Siebzehnrubl
Project Type
Other
Research Theme
Neuroscience and Mental Health
Project Summary Download
Summary
How do glioblastoma stem cells evade therapy and drive tumour recurrence? This project will address this question by investigating how FGF2-FGFR1 signalling regulates protein homeostasis in these highly aggressive cells. Using patient-derived models, multi-OMICs datasets, proteomics and functional laboratory assays, you will identify novel molecular mechanisms underlying stemness and treatment resistance. The project combines computational and experimental approaches, providing broad training in cancer biology, bioinformatics and molecular techniques. You will have the opportunity to develop your own analytical strategies, help prioritise candidate genes for validation, and contribute directly to discovering new therapeutic opportunities for brain cancer.
Can the project be completed part time?
Yes
Lead Supervisor
Dr Florian Siebzehnrubl
Lead Supervisor Email
University Affiliation
Cardiff University
