Project Code
NMH27Ex Flynn
Project Type
Wet lab
Research Theme
Neuroscience and Mental Health
Project Summary Download
Summary
What are the first things that go wrong in neurodevelopmental disorders? This project will use human stem cells to grow early brain cells, then rapidly switch off selected disease-linked transcription factors. By measuring the immediate effects on chromatin accessibility and gene activity, using advanced genomics approaches such as CUT&Tag and RNA-seq, we can uncover how disrupted gene control leads to neurodevelopmental disorders including intellectual disability, autism, epilepsy and speech impairment. The student will learn cutting-edge stem cell, genome editing and genomics methods while helping answer a fundamental question about how human brain development goes wrong.
Can the project be completed part time?
No
Lead Supervisor
Dr Sean Flynn
Lead Supervisor Email
University Affiliation
University of Exeter
