Cracking the ribosome code of brain development

Project Code

NMH27Ex Bernard

Project Type

Wet lab

Research Theme

Neuroscience and Mental Health

Project Summary Download

Summary

What if ribosomes carried a code that helps build the brain? Ribosomes are complex molecular structures that play active roles in protein synthesis. During development, progenitor cells generate a diverse pool of neurons that form the adult brain circuits, but the role of protein synthesis in this key developmental process is still poorly understood. Using zebrafish and mouse models, this project will compare ribosomes in progenitors and newly born neurons, combining developmental neuroscience with structural biology imaging. This research will uncover fundamental mechanisms of brain development and provide insight into processes disrupted in neurodevelopmental disorders.

Can the project be completed part time?

No

Lead Supervisor

Dr Clémence Bernard

Lead Supervisor Email

c.bernard@exeter.ac.uk

University Affiliation

University of Exeter

Back to top ↑