Project Code NMH27Ba Licchesi Project Type Wet lab Research Theme Neuroscience and Mental Health Project Summary Download Summary Rare genetic variants are a major cause of neurodevelopmental disorders, including autism, epilepsy and intellectual disability, yet the underlying disease mechanisms remain…
Boosting the Brain Cell Recycling System: Peptide Activation of TFEB in Neurodegeneration
Project Code NMH27Ba Mason Project Type Other Research Theme Neuroscience and Mental Health Project Summary Download Summary Many neurodegenerative diseases, including Parkinson’s disease, involve failure of the cell’s waste-clearance system, allowing damaged proteins and organelles to accumulate. TFEB is a…
You snooze, you win: harnessing hibernation biology for organ protection
Project Code NMH27Br Ambler Project Type Wet lab Research Theme Neuroscience and Mental Health Project Summary Download Summary Hibernating animals survive with barely-beating hearts and minimal oxygen. What if we could borrow that trick for critically ill patients? We’ve found…
Uncovering interneuron dysfunction in a mouse model of schizophrenia
Project Code NMH27Br Anastasiades Project Type Wet lab Research Theme Neuroscience and Mental Health Project Summary Download Summary This project seeks to understand how disease-causing mutations linked to neurodevelopmental disorders, such as schizophrenia, alter cell types in the brain. The…
Cerebellar orchestration of social behaviour
Project Code NMH27Br Cahill Project Type Other Research Theme Neuroscience and Mental Health Project Summary Download Summary The cerebellum is increasingly recognised to contribute to behavioural flexibility and social cognition. Cerebellar changes are also a major risk factor for developing…
Timing is Everything: Aligning Mealtime and Drug Treatment with the Body Clock to Fight Obesity
Project Code NMH27Br Chrobok Project Type Wet lab Research Theme Neuroscience and Mental Health Project Summary Download Summary Most physiological processes, including feeding, follow circadian (~24h) cycles. In mammals, these rhythms are generated by endogenous ‘body clocks’ within the brain.…
Alternative fates of PINK1 and its role in mitochondrial quality control, energy production and Parkinson’s Disease
Project Code NMH27Br Collinson Project Type Wet lab Research Theme Neuroscience and Mental Health Project Summary Download Summary Mitochondria are vital for energy production, cellular homeostasis, and health. This project explores how PINK1, key to mitochondrial quality control, is imported…
Molecular basis of CASK mutations and their role in neural development
Project Code NMH27Br Corey Project Type Other Research Theme Neuroscience and Mental Health Project Summary Download Summary This interdisciplinary PhD project will investigate how disease-causing mutations alter the structure and function of CASK, a key protein required for synaptic development,…
What drives the pain? Exploring the peripheral component in models of central sensitisation
Project Code NMH27Br Dunham Project Type Wet lab Research Theme Neuroscience and Mental Health Project Summary Download Summary Chronic primary pain affects 8 million UK adults, but we still do not understand what drives pain when there is no identifiable…
Gatekeepers of GPCR Signalling: Degradation Pathways in Health and Disease
Project Code NMH27Br Grieve Project Type Wet lab Research Theme Neuroscience and Mental Health Project Summary Download Summary Neuropsychiatric disorders remain among the greatest challenges in medicine, yet we still lack a detailed understanding of how changes at the molecular…