Project Code
NMH27Br Collinson
Project Type
Wet lab
Research Theme
Neuroscience and Mental Health
Project Summary Download
Summary
Mitochondria are vital for energy production, cellular homeostasis, and health. This project explores how PINK1, key to mitochondrial quality control, is imported into mitochondria and how its misdirection contributes to early-onset Parkinson’s disease. We have discovered a new pathway for PINK1 import, suggesting its structural plasticity influences its fate and function. Using advanced biochemical and computational tools, the project will investigate how PINK1 variants associated with Parkinson’s affect mitochondrial function, and progression of disease — exploring also how this can be corrected. This interdisciplinary project offers exciting opportunities to uncover novel mechanisms of neuro-degeneration and training in cutting-edge research techniques.
Can the project be completed part time?
Yes
Lead Supervisor
Professor Ian Collinson
Lead Supervisor Email
University Affiliation
University of Bristol
