The interplay between genetics and brain development in schizophrenia

Project Code

MRCNMH24Br Ashby

Research Theme

Neuroscience and Mental Health

Full Project Description

Please download the below document for a full project description and to see the full supervisory team.


Schizophrenia is a severe neurodevelopmental psychiatric disorder with high heritability, but we don’t know how genetic variation leads to abnormal maturation of brain function. Disruption of the SETD1A gene is linked to elevated schizophrenia risk. In this project, we will investigate the cortical development of a mouse model of SETD1A deficiency using molecular, electrophysiological, imaging and behavioural techniques to link aberrant neurobiology to pathology.

Lead Supervisor

Dr Michael Ashby

Lead Supervisor Email

University Affiliation